Furin-targeting activity-based probes with phosphonate and phosphinate esters as warheads-Reference-Cited by-同舟云学术

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Furin-targeting activity-based probes with phosphonate and phosphinate esters as warheads

Published:2023 Issue:32 Volume:21 Page:6498-6502
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ji Shanping¹,Verhelst Steven H. L.¹²^ORCID

Affiliation:

1. Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven – University of Leuven, 3000 Leuven, Belgium

2. AG Chemical Proteomics, Leibniz Institute for Analytical Sciences – ISAS, 44227 Dortmund, Germany

Abstract

Novel phosphonate and phosphinate ester activity-based probes allow covalent labeling of furin in cells.

Funder

China Scholarship Council

Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00948C

Reference27 articles.

1. MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

2. Furin at the cutting edge: From protein traffic to embryogenesis and disease

3. The proprotein convertase furin in cancer: more than an oncogene

4. Proteolytic activation of SARS‐CoV‐2 spike protein

5. Therapeutic uses of furin and its inhibitors: a patent review

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