Redefining the TGR5 Triterpenoid Binding Pocket at the C-3 Position-Reference-Cited by-同舟云学术

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Redefining the TGR5 Triterpenoid Binding Pocket at the C-3 Position

Published:2010-10-26 Issue:12 Volume:5 Page:1983-1988
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Genet Cédric,Schmidt Céline,Strehle Axelle,Schoonjans Kristina,Auwerx Johan,Saladin Régis,Wagner Alain

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201000329/fullpdf

Reference13 articles.

1. Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes

2. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

3. A G Protein-coupled Receptor Responsive to Bile Acids

4. Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1

5. TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

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1. The role of botanical triterpenoids and steroids in bile acid metabolism, transport, and signaling: Pharmacological and toxicological implications;Acta Pharmaceutica Sinica B;2024-08

2. Terpenoids as potential phytoconstituent in the treatment of diabetes: From preclinical to clinical advancement;Phytomedicine;2024-07

3. Update on the development of TGR5 agonists for human diseases;European Journal of Medicinal Chemistry;2024-05

4. Synthesis and Intramolecular Cyclization of 2,3-Seco-Lupane Triterpenoids with an Ethylketone Fragment;Chemistry of Natural Compounds;2023-01

5. Effect of modification of betulinic acid at the C3-carbon atom of homolupane triterpenoids on the antiproliferative activity in vitro;The Journal of Steroid Biochemistry and Molecular Biology;2022-11

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