Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes-Reference-Cited by-同舟云学术

Structure−Activity Relationship Study of Betulinic Acid, A Novel and Selective TGR5 Agonist, and Its Synthetic Derivatives: Potential Impact in Diabetes

Published:2009-11-13 Issue:1 Volume:53 Page:178-190
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Genet Cédric¹²,Strehle Axelle³,Schmidt Céline⁴,Boudjelal Geoffrey⁵,Lobstein Annelise⁶,Schoonjans Kristina⁷,Souchet Michel⁵,Auwerx Johan⁷,Saladin Régis⁴,Wagner Alain¹

Affiliation:

1. UMR/CNRS 7199, Faculté de pharmacie, Université Louis Pasteur, 67404 Illkirch, France

2. Novalix, Bioparc, Boulevard Sébastien Brant, BP30170, 67405 Illkirch, France

3. Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/université Louis Pasteur, 67404 Illkirch, France

4. PhytoDia, Bioparc, Boulevard Sébastien Brant, BP10413, 67404 Illkirch, France

5. Harmonic Pharma, Espace Transfert, 615 rue du Jardin Botanique, 54600 Villers les Nancy, France

6. UMR/CNRS 7175, Faculté de pharmacie, Université Louis Pasteur, 67404 Illkirch, France

7. Swiss Federal Institute of Technology, CH-1015 Lausanne, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm900872z

Reference37 articles.

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4. Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

5. Itoh, F.; Hinuma, S.; Kanzaki, N.; Miki, T.; Kawamata, Y.; Oi, S.; Tawaraishi, T.; Ishichi, Y.; Hirohashi, M.Preparation of aromatic ring-fused cyclic compounds as TGR5 receptor agonists. 2004-JP706 2004067008, 20040127, 2004.

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