Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases

Author:

Břehová Petra1,Šmídková Markéta1,Skácel Jan1,Dračínský Martin1,Mertlíková-Kaiserová Helena1,Velasquez Monica P. Soto2,Watts Val J.2,Janeba Zlatko1ORCID

Affiliation:

1. The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences; Flemingovo nám. 2 166 10 Prague 6 Czech Republic

2. Department of Medicinal Chemistry and Molecular Pharmacology; College of Pharmacy; Purdue University; 575 Stadium Mall Drive West Lafayette IN 47907 USA

Funder

Institute of Organic Chemistry and Biochemistry (IOCB) of the Czech Academy of Sciences

Ministry of Interior of the Czech Republic

Ministry of Education of the Czech Republic

Gilead Sciences

US National Institutes of Health (NIH)

Purdue University

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference78 articles.

1. Bordetella pertussis, the Causative Agent of Whooping Cough, Evolved from a Distinct, Human-Associated Lineage of B. bronchiseptica

2. Pertussis vaccines Weekly Epidemiological Record 2010 85

3. Pertussis: Microbiology, Disease, Treatment, and Prevention

4. Recommended Antimicrobial Agents for the Treatment and Postexposure Prophylaxis of Pertussis Morbidity and Mortality Weekly Report www.cdc.gov/mmwr/preview/mmwrhtml/rr5414a1.htm

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