Synthesis, Antiviral Activity, and Structure–Activity Relationship of 1,3‐Benzodioxolyl Pyrrole‐Based Entry Inhibitors Targeting the Phe43 Cavity in HIV‐1 gp120-Reference-Cited by-同舟云学术

Synthesis, Antiviral Activity, and Structure–Activity Relationship of 1,3‐Benzodioxolyl Pyrrole‐Based Entry Inhibitors Targeting the Phe43 Cavity in HIV‐1 gp120

Published:2018-10-19 Issue:21 Volume:13 Page:2332-2348
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Curreli Francesca¹,Belov Dmitry S.²,Ahmed Shahad¹,Ramesh Ranjith R.¹,Kurkin Alexander V.²,Altieri Andrea²,Debnath Asim K.¹^ORCID

Affiliation:

1. Laboratory of Molecular Modeling & Drug DesignLindsley F. Kimball Research Institute, New York Blood Center 310 East 67th Street New York NY 10065 USA

2. EDASA Scientific, Scientific ParkMoscow State University Leninskie Gory Boulevard 75, 77-101b 119992 Moscow Russia

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201800534

Reference41 articles.

2. Identification of N-phenyl-N′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of HIV-1 entry inhibitors that prevent gp120 binding to CD4

3. Thermodynamics of Binding of a Low-Molecular-Weight CD4 Mimetic to HIV-1 gp120