Targeting an EGFR Water Network with 4‐Anilinoquin(az)oline Inhibitors for Chordoma-Reference-Cited by-同舟云学术

Targeting an EGFR Water Network with 4‐Anilinoquin(az)oline Inhibitors for Chordoma

Published:2019-09-23 Issue:19 Volume:14 Page:1693-1700
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Asquith Christopher R. M.¹²^ORCID,Maffuid Kaitlyn A.³,Laitinen Tuomo⁴,Torrice Chad D.³,Tizzard Graham J.⁵,Crona Daniel J.³⁶,Zuercher William J.²⁶

Affiliation:

1. Department of PharmacologySchool of MedicineUniversity of North Carolina Chapel Hill NC 27599 USA

2. Structural Genomics Consortium, UNC Eshelman School of PharmacyUniversity of North Carolina Chapel Hill NC 27599 USA

3. Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of PharmacyUniversity of North Carolina Chapel Hill NC 27599 USA

4. School of PharmacyFaculty of Health SciencesUniversity of Eastern Finland 70211 Kuopio Finland

5. School of ChemistryUniversity of Southampton Southampton SO17 1BJ UK

6. Lineberger Comprehensive Cancer CenterUniversity of North Carolina Chapel Hill NC 27599 USA

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900428

Reference27 articles.

1. Cancer Fact Sheet No. 297 World Health Organization 2018:https://www.who.int/news-room/fact-sheets/detail/cancer.

3. Kinase inhibitors: the road ahead

4. FDA-approved small-molecule protein kinase inhibitors Blue Ridge Institute for Medical Research Horse Shoe NC (USA):http://www.brimr.org/PKI/PKIs.htm.

5. Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

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