Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety-Reference-Cited by-同舟云学术

Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety

Published:2019-08-05 Issue:16 Volume:14 Page:1560-1572
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Cohen Frederick¹^ORCID,Aggen James B.¹,Andrews Logan D.¹^ORCID,Assar Zahra²^ORCID,Boggs Jen¹,Choi Taylor¹,Dozzo Paola¹,Easterday Ashton N.¹,Haglund Cat M.¹,Hildebrandt Darin J.¹,Holt Melissa C.²^ORCID,Joly Kristin³,Jubb Adrian¹,Kamal Zeeshan⁴,Kane Timothy R.¹,Konradi Andrei W.⁵,Krause Kevin M.¹,Linsell Martin S.¹,Machajewski Timothy D.¹,Miroshnikova Olga⁴,Moser Heinz E.¹,Nieto Vincent¹,Phan Thu⁴,Plato Craig³,Serio Alisa W.¹,Seroogy Julie¹,Shakhmin Anton⁴,Stein Adam J.²^ORCID,Sun Alex D.⁴,Sviridov Serguei⁴,Wang Zhan⁴,Wlasichuk Kenneth¹,Yang Wen⁴,Zhou Xiaoming⁶,Zhu Hai⁴,Cirz Ryan T.¹^ORCID

Affiliation:

1. Achaogen Inc. 1 Tower Place, Suite 400 South San Francisco CA 94080 USA

2. Cayman Chemical Co. 1180 East Ellsworth Ann Arbor MI 48108 USA

3. Plato BioPharma Inc. 7581 West 103rd Avenue, Unit 300 Westminster CO 80021 USA

4. Nanosyn Inc. 3100 Central Expressway Santa Clara CA 95051 USA

5. Konradi Molecular 30 Victoria Road Burlingame CA 94010 USA

6. Pharmaron Inc. 6 Tai-He Road, BDA Beijing 100176 China

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.201900287

Reference24 articles.

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2. Antibiotic Resistance Threats in the United States 2013 Centers for Disease Control and Prevention:www.cdc.gov/drugresistance/threat-report-2013(accessed February 27 2019).

3. Notes from the Field: Pan-Resistant New Delhi Metallo-Beta-Lactamase-Producing Klebsiella pneumoniae — Washoe County, Nevada, 2016

4. Antibacterial Drug Discovery: Some Assembly Required

5. Drugs for bad bugs: confronting the challenges of antibacterial discovery

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