On the Implication of Water on Fragment-to-Ligand Growth in Kinase Binding Thermodynamics-Reference-Cited by-同舟云学术

On the Implication of Water on Fragment-to-Ligand Growth in Kinase Binding Thermodynamics

Published:2018-08-23 Issue:18 Volume:13 Page:1988-1996
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Wienen-Schmidt Barbara¹,Wulsdorf Tobias¹,Jonker Hendrik R. A.²,Saxena Krishna²,Kudlinzki Denis²,Linhard Verena²,Sreeramulu Sridhar²,Heine Andreas¹^ORCID,Schwalbe Harald²^ORCID,Klebe Gerhard¹^ORCID

Affiliation:

1. Institut für Pharmazeutische Chemie; Philipps-Universität Marburg; Marbacher Weg 6 35032 Marburg Germany

2. Institut für Organische Chemie und Chemische Biologie, Deutsches Zentrum für Translationale Krebsforschung (DKTK); Johann Wolfgang Goethe-Universität Frankfurt; Max-von-Laue-Straße 7, N160-3.14 60438 Frankfurt am Main Germany

Funder

LOEWE Schwerpunkt

FP7 Ideas: European Research Council

H2020 European Research Council

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/cmdc.201800438/fullpdf

Reference36 articles.

1. Twenty years on: the impact of fragments on drug discovery