Antibody Epitope of Human α-Galactosidase A Revealed by Affinity Mass Spectrometry: A Basis for Reversing Immunoreactivity in Enzyme Replacement Therapy of Fabry Disease-Reference-Cited by-同舟云学术

Antibody Epitope of Human α-Galactosidase A Revealed by Affinity Mass Spectrometry: A Basis for Reversing Immunoreactivity in Enzyme Replacement Therapy of Fabry Disease

Published:2018-04-16 Issue:9 Volume:13 Page:909-915
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Kukacka Zdenek¹²,Iurascu Marius¹²,Lupu Loredana¹²,Rusche Hendrik¹²,Murphy Mary³,Altamore Lorenzo⁴⁵⁶,Borri Fabio⁴⁵⁶,Maeser Stefan¹²,Papini Anna Maria⁴⁵⁶,Hennermann Julia⁷,Przybylski Michael¹²^ORCID

Affiliation:

1. Steinbeis Centre for Biopolymer Analysis and Biomedical Mass Spectrometry; 65428 Rüsselsheim am Main Germany

2. Department of Chemistry; University of Konstanz; 78457 Konstanz Germany

3. Ametek Reichert Technologies; Depew NY 14043 USA

4. French-Italian Interdepartmental Laboratory of Peptide and Protein Chemistry and Biology; Università degli Studi di Firenze; 50019 Sesto Fiorentino Italy

5. Dipartimento di Chimica “Ugo Schiff”; Università degli Studi di Firenze; Via della Lastruccia 13 50019 Sesto Fiorentino Italy

6. PeptLab@UCP and Laboratory of Chemical Biology EA4505; Université Paris-Seine; 5 Mail Gay-Lussac 95031 Cergy-Pontoise France

7. Department of Pediatrics, Villa Metabolica; Universitätsmedizin Mainz; 55130 Mainz Germany

Funder

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference28 articles.

1. The role of antibodies in enzyme treatments and therapeutic strategies

2. Treatment of Lysosomal Storage Diseases: Recent Patents and Future Strategies

3. Enzyme therapy for Fabry disease: Neutralizing antibodies toward agalsidase alpha and beta

4. Enzyme replacement therapy for Fabry disease: lessons from two α-galactosidase A orphan products and one FDA approval

5. The impact of antibodies on clinical outcomes in diseases treated with therapeutic protein: Lessons learned from infantile Pompe disease

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