Synthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters-Reference-Cited by-同舟云学术

Synthesis and SAR Study of Anticancer Protoflavone Derivatives: Investigation of Cytotoxicity and Interaction with ABCB1 and ABCG2 Multidrug Efflux Transporters

Published:2017-05-23 Issue:11 Volume:12 Page:850-859
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Dankó Balázs¹,Tóth Szilárd²,Martins Ana³⁴,Vágvölgyi Máté¹,Kúsz Norbert¹,Molnár Joseph³,Chang Fang-Rong⁵⁶⁷,Wu Yang-Chang⁵⁸⁹,Szakács Gergely²¹⁰,Hunyadi Attila¹¹¹^ORCID

Affiliation:

1. Institute of Pharmacognosy; University of Szeged; Szeged Hungary

2. Institute of Enzymology; Research Centre for Natural Sciences, Hungarian Academy of Sciences; Budapest Hungary

3. Department of Medical Microbiology and Immunobiology; Faculty of Medicine; University of Szeged; Szeged Hungary

4. Current address: Synthetic Systems Biology Unit; Institute of Biochemistry; Biological Research Centre; Temesvári krt. 62 6726 Szeged Hungary

5. Graduate Institute of Natural Products; Kaohsiung Medical University; Kaohsiung Taiwan, R.O.C.

6. Cancer Center; Kaohsiung Medical University Hospital; Kaohsiung Taiwan, R.O.C.

7. R&D Center of Chinese Herbal Medicines & New Drugs, College of Pharmacy; Kaohsiung Medical University; Kaohsiung Taiwan, R.O.C.

8. Research Center for Natural Products and Drug Development; Kaohsiung Medical University; Kaohsiung Taiwan, R.O.C.

9. Department of Medical Research; Kaohsiung Medical University Hospital; Kaohsiung Taiwan, R.O.C.

10. Institute of Cancer Research; Medical University Vienna; Vienna Austria

11. Interdisciplinary Centre for Natural Products; University of Szeged; Szeged Hungary

Funder

National Research, Development and Innovation Office, Hungary

H2020 European Research Council

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Reference27 articles.

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3. Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?

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5. Targeting multidrug resistance in cancer

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