Plant-Based Products Originating from Serbia That Affect P-glycoprotein Activity-Reference-Cited by-同舟云学术

Plant-Based Products Originating from Serbia That Affect P-glycoprotein Activity

Published:2024-09-11 Issue:18 Volume:29 Page:4308
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Dinić Jelena¹^ORCID,Podolski-Renić Ana¹^ORCID,Novaković Miroslav²^ORCID,Li Liang³^ORCID,Opsenica Igor⁴^ORCID,Pešić Milica¹^ORCID

Affiliation:

1. Institute for Biological Research “Siniša Stanković”—National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia

2. Institute of Chemistry, Technology and Metallurgy—National Institute of the Republic of Serbia, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia

3. Key Laboratory of Bioactive Substance and Function of Natural Medicines, State Key Laboratory of Respiratory Health and Multimorbidity, NHC Key Laboratory of Biotechnology for Microbial Drugs, Department of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Tiantan Xili, Beijing 100050, China

4. Faculty of Chemistry, University of Belgrade, Studentski trg 12–16, 11158 Belgrade, Serbia

Abstract

Our review paper evaluates the impact of plant-based products, primarily derived from plants from Serbia, on P-glycoprotein (P-gp) activity and their potential in modulating drug resistance in cancer therapy. We focus on the role and regulation of P-gp in cellular physiology and its significance in addressing multidrug resistance in cancer therapy. Additionally, we discuss the modulation of P-gp activity by 55 natural product drugs, including derivatives for some of them, based on our team’s research findings since 2011. Specifically, we prospect into sesquiterpenoids from the genera Artemisia, Curcuma, Ferula, Inula, Petasites, and Celastrus; diterpenoids from the genera Salvia and Euphorbia; chalcones from the genera Piper, Glycyrrhiza, Cullen, Artemisia, and Humulus; riccardins from the genera Lunularia, Monoclea, Dumortiera, Plagiochila, and Primula; and diarylheptanoids from the genera Alnus and Curcuma. Through comprehensive analysis, we aim to highlight the potential of natural products mainly identified in plants from Serbia in influencing P-gp activity and overcoming drug resistance in cancer therapy, while also providing insights into future perspectives in this field.

Funder

Ministry of Science, Technological Development and Innovation of the Republic of Serbia

“Belt and Road Initiative” Innovative Talent Exchange Foreign Expert Project

Publisher

MDPI AG

Link

https://www.mdpi.com/1420-3049/29/18/4308/pdf

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