A Hydrogen Peroxide Activatable Gemcitabine Prodrug for the Selective Treatment of Pancreatic Ductal Adenocarcinoma

Author:

Matsushita Katsunori12,Okuda Takumi3ORCID,Mori Shohei3,Konno Masamitsu24ORCID,Eguchi Hidetoshi1,Asai Ayumu24,Koseki Jun24ORCID,Iwagami Yoshifumi1,Yamada Daisaku15,Akita Hirofumi1,Asaoka Tadafumi1,Noda Takehiro1,Kawamoto Koichi16,Gotoh Kunihito1,Kobayashi Shogo1,Kasahara Yuuya37,Morihiro Kunihiko378,Satoh Taroh2,Doki Yuichiro1,Mori Masaki19,Ishii Hideshi4,Obika Satoshi37ORCID

Affiliation:

1. Department of Gastroenterological SurgeryGraduate School of MedicineOsaka University 2-2 Yamadaoka Suita Osaka 565-0871 Japan).

2. Department of Frontier Science for Cancer and ChemotherapyGraduate School of MedicineOsaka University 2-2 Yamadaoka Suita Osaka 565-0871 Japan

3. Graduate School of Pharmaceutical SciencesOsaka University 1-6 Yamadaoka Suita Osaka 565-0871 Japan

4. Department of Medical Data ScienceGraduate School of MedicineOsaka University 2-2 Yamadaoka Suita Osaka 565-0871 Japan

5. Present address: Department of Digestive SurgeryOsaka International Cancer Institute 3-1-69 Otemae, Chuo-ku Osaka Osaka 541-8567 Japan

6. Present address: Kinki Regional Bureau of Health and WelfareMinistry of Health, Labour and Welfare 4-1-76 Nonin Bashi, Chuo-ku Osaka Osaka 540-0008 Japan

7. National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN) 7-6-8 Saito-Asagi Ibaraki Osaka 567-0085 Japan

8. Present address: Department of Chemistry and BiotechnologyGraduate School of EngineeringThe University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-8656 Japan

9. Present address: Department of Surgery and ScienceGraduate School of Medical SciencesKyushu University 3-1-1 Maidashi, Higashi-ku Fukuoka 812-8582 Japan

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

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