A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells <i>versus</i> neutrophils selectivity of camptothecin-Reference-Cited by-同舟云学术

A concept of dual-responsive prodrugs based on oligomerization-controlled reactivity of ester groups: an improvement of cancer cells versus neutrophils selectivity of camptothecin

Published:2024 Issue:4 Volume:15 Page:1189-1197
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Klemt Insa¹^ORCID,Reshetnikov Viktor¹,Dutta Subrata¹,Bila Galyna²,Bilyy Rostyslav²^ORCID,Cuartero Itziar Cossío³,Hidalgo Andrés³,Wünsche Adrian¹,Böhm Maximilian¹,Wondrak Marit⁴,Kunz-Schughart Leoni A.⁴⁵^ORCID,Tietze Rainer⁶^ORCID,Beierlein Frank⁷⁸,Imhof Petra⁷⁸^ORCID,Gensberger-Reigl Sabrina⁹^ORCID,Pischetsrieder Monika⁹^ORCID,Körber Marlies¹,Jost Tina¹⁰,Mokhir Andriy¹^ORCID

Affiliation:

1. Department of Chemistry and Pharmacy, Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), 91058 Erlangen, Germany

2. Department of Histology, Cytology and Embryology, Danylo Halytsky Lviv National Medical University, 79010 Lviv, Ukraine

3. Program of Cardiovascular Regeneration, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), C. Melchor Fernández Almagro, 3, 28029 Madrid, Spain

4. OncoRay, National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

5. National Center for Tumor Diseases (NCT), Partner Site Dresden, Germany

6. Department of Otorhinolaryngology, Head and Neck Surgery, Section of Experimental Oncology and Nanomedicine (SEON), FAU, University Hospital, 91054 Erlangen, Germany

7. Erlangen National High Performance Computing Center (NHR@FAU), FAU, 91058 Erlangen, Germany

8. Computer-Chemistry-Center, Department of Chemistry and Pharmacy, FAU, Germany

9. Department of Chemistry and Pharmacy, Food Chemistry, FAU, 91058 Erlangen, Germany

10. Department of Radiation Oncology, FAU, University Hospital, 91054 Erlangen, Germany

Abstract

We introduced a concept of prodrugs activated by H2O2 and mitochondrial OH−, which is applicable to camptothecin and its derivatives.

Funder

H2020 Future and Emerging Technologies

Deutsche Forschungsgemeinschaft

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00609C

Reference42 articles.

1. Topoisomerase I inhibitors: camptothecins and beyond

2. The Current Status of Camptothecin Analogues as Antitumor Agents

3. Bleomycins: towards better therapeutics

4. Myelotoxicity and Dose Intensity of Chemotherapy: Reporting Practices From Randomized Clinical Trials

5. Microtubules as a target for anticancer drugs

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