Blood plasma level determination using an automated LC-MSn screening system and electronically stored calibrations exemplified for 22 drugs and two active metabolites often requested in emergency toxicology

Author:

Caspar Achim T.1,Meyer Markus R.1,Maurer Hans H.1ORCID

Affiliation:

1. Department of Experimental and Clinical Toxicology; Institute of Experimental and Clinical, Pharmacology and Toxicology, Saarland University; Homburg Germany

Publisher

Wiley

Subject

Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry

Reference37 articles.

1. A multi-analyte approach to help in assessing the severity of acute poisonings - Development and validation of a fast LC-MS/MS quantification approach for 45 drugs and their relevant metabolites with one-point calibration;Michely;Drug Test Anal.,2018

2. Development and validation of a fast and simple multi-analyte procedure for quantification of 40 drugs relevant to emergency toxicology using GC-MS and one-point calibration;Meyer;Drug Test Anal.,2014

3. Demands on scientific studies in clinical toxicology;Maurer;Forensic Sci Int.,2007

4. How can analytical diagnostics in clinical toxicology be successfully performed today?;Maurer;Ther Drug Monit.,2012

5. Automated mass spectral deconvolution and identification system for GC-MS screening for drugs, poisons, and metabolites in urine;Meyer;Clin Chem.,2010

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