Chimeric antigen receptor‐modified human regulatory T cells that constitutively express IL‐10 maintain their phenotype and are potently suppressive-Reference-Cited by-同舟云学术

Chimeric antigen receptor‐modified human regulatory T cells that constitutively express IL‐10 maintain their phenotype and are potently suppressive

Published:2021-08-08 Issue:10 Volume:51 Page:2522-2530
ISSN:0014-2980
Container-title:European Journal of Immunology
language:en
Short-container-title:Eur J Immunol

Author:

Mohseni Yasmin R.¹,Saleem Adeel¹²³,Tung Sim L.¹,Dudreuilh Caroline¹,Lang Cameron²,Peng Qi¹,Volpe Alessia²,Adigbli George⁴,Cross Amy⁴,Hester Joanna⁴,Farzaneh Farzin⁵,Scotta Cristiano¹^ORCID,Lechler Robert I.¹,Issa Fadi⁴^ORCID,Fruhwirth Gilbert O.²,Lombardi Giovanna¹

Affiliation:

1. MRC Centre for Transplantation Immunology School of Immunology and Microbial Sciences, King's College London London UK

2. Imaging Therapies and Cancer Group Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Studies, King's College London London UK

3. Department of Haematology and Precision Medicine Kings College Hospital London UK

4. Transplantation Research & Immunology Group, Nuffield Department of Surgical Sciences University of Oxford, Oxford, UK

5. Department of Haematological Medicine School of Cancer and Pharmaceutical Studies, King's College London London UK

Funder

Medical Research Council

British Heart Foundation

Cancer Research UK

Wellcome Trust

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.202048934

Reference44 articles.

1. Human FoxP3+ regulatory T cells in systemic autoimmune diseases

2. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

3. Cellular therapies in organ transplantation

4. Regulatory T cells for tolerance

5. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

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