Production of Fructo‐Oligosaccharides in Membrane Bioreactor Using Rotating Ceramic Membrane Disc

Author:

Fan Rong1234ORCID,Tissen Dennis3,Su Xinwei12,Schmitz Oliver3,Ebrahimi Mehrdad3ORCID,Maguire Nicolas A. P.3,Czermak Peter34ORCID

Affiliation:

1. Institute of Process Engineering of Chinese Academy of Sciences State Key Laboratory of Biochemical Engineering No. 1 Bei-Er Jie 100190 Beijing China

2. Key Laboratory of Biopharmaceutical Preparation and Delivery (Chinese Academy of Sciences) No. 1 Bei-Er Jie 100190 Beijing China

3. University of Applied Sciences Mittelhessen Institute of Bioprocess Engineering and Pharmaceutical Technology Wiesenstraße 14 35390 Giessen Germany

4. Justus-Liebig-University Department of Biology and Chemistry Heinrich Buff Ring 17 35392 Giessen Germany

Abstract

AbstractFructo‐oligosaccharides (FOS) are often produced via enzymatic conversion in industry. Enzyme membrane bioreactor (EMBR) can enhance the catalytic efficiency by in‐situ product removal. Its major bottleneck is the fouling caused by the deposition of enzyme on membrane surface. An EMBR system with a compact rotating disc device was established for continuous FOS production. This study further investigated the influences of the membrane rotation on the flux control and enzyme activity. The speed of 600 rpm was a good compromise between flux and fouling control, which stabilized the flux at ∼80 L m−2h−1 during the process. Moreover, the rotation led to an increase in the rejection of enzymes by 20 %, compensating the loss of enzyme due to the inhomogeneous distribution of membrane pore size.

Funder

National Key Research and Development Program of China

Hessisches Ministerium für Wissenschaft und Kunst

Publisher

Wiley

Reference35 articles.

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3. Potential application of commercial enzyme preparations for industrial production of short-chain fructooligosaccharides

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