The Generation, Detection, and Effects of Reactive Drug Metabolites

Author:

Stachulski Andrew V.1,Baillie Thomas A.2,Kevin Park B.3,Scott Obach R.4,Dalvie Deepak K.5,Williams Dominic P.3,Srivastava Abhishek3,Regan Sophie L.3,Antoine Daniel J.3,Goldring Christopher E. P.3,Chia Alvin J. L.3,Kitteringham Neil R.3,Randle Laura E.6,Callan Hayley3,Castrejon J. Luis3,Farrell John3,Naisbitt Dean J.3,Lennard Martin S.7

Affiliation:

1. Department of Chemistry, Robert Robinson Laboratories; University of Liverpool; Liverpool; L69 7ZD; UK

2. School of Pharmacy; University of Washington; Box 357631; Seattle; Washington; 98195-7631

3. Department of Molecular and Clinical Pharmacology; MRC Centre for Drug Safety Science; Institute of Translational Medicine; University of Liverpool; Sherrington Buildings, Ashton Street; Liverpool L69 3GE; UK

4. Pharmacokinetics, Dynamics and Metabolism; Pfizer Worldwide Research & Development; Groton; Connecticut 06340

5. Pharmacokinetics, Dynamics and Metabolism; Pfizer Worldwide Research & Development; La Jolla; California 94121

6. School of Pharmacy and Biomolecular Sciences, Faculty of Science; Liverpool John Moores University; James Parsons Building, Byrom Street; Liverpool L3 3AF; UK

7. Academic Unit of Medical Education; University of Sheffield; 85 Wilkinson Street; Sheffield S10 2GJ; UK

Publisher

Wiley

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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