Family History in Parkinson's Disease: A National Cross‐Sectional Study-Reference-Cited by-同舟云学术

Family History in Parkinson's Disease: A National Cross‐Sectional Study

Published:2024-09-13 Issue: Volume: Page:
ISSN:2330-1619
Container-title:Movement Disorders Clinical Practice
language:en
Short-container-title:Movement Disord Clin Pract

Author:

Arienti Federica¹²^ORCID,Casazza Giovanni³⁴,Franco Giulia¹²,Lazzeri Giulia²⁵^ORCID,Monfrini Edoardo¹²,Di Maio Alessandro¹²,Erro Roberto⁶^ORCID,Barone Paolo⁶,Tamma Filippo⁷,Caputo Elena⁷,Volontè Maria Antonietta⁸,Cacciaguerra Laura⁸,Pilotto Andrea⁹^ORCID,Padovani Alessandro⁹,Comi Cristoforo¹⁰,Magistrelli Luca⁵^ORCID,Valzania Franco¹¹,Cavallieri Francesco¹¹^ORCID,Avanzino Laura¹²¹³^ORCID,Marchese Roberta¹³,Sensi Mariachiara¹⁴^ORCID,Carroli Giorgia¹⁴,Eleopra Roberto¹⁵,Cilia Roberto¹⁵^ORCID,Spagnolo Francesca¹⁶,Tessitore Alessandro¹⁷,De Micco Rosa¹⁷^ORCID,Ceravolo Roberto¹⁸^ORCID,Palermo Giovanni¹⁸,Malaguti Maria Chiara¹⁹,Lopiano Leonardo²⁰²¹,Tocco Pierluigi²²,Sorbera Chiara²³,Tinazzi Michele²⁴^ORCID,Ciammola Andrea²⁵,Ottaviani Donatella²⁶,Valente Enza Maria²⁷²⁸^ORCID,Albanese Alberto²⁹^ORCID,Blandini Fabio⁴,Canesi Margherita³⁰,Antonini Angelo³¹^ORCID,Carecchio Miryam³¹,Fetoni Vincenza³²,Colosimo Carlo³³,Volpe Daniele³⁴,Tambasco Nicola³⁵^ORCID,Cossu Giovanni³⁶,Zappia Mario³⁷^ORCID, ,Di Fonzo Alessio¹^ORCID

Affiliation:

1. Foundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Neurology Unit Milan Italy

2. Dino Ferrari Center, Neuroscience Section, Department of Pathophysiology and Transplantation University of Milan Milan Italy

3. Department of Clinical Sciences and Community Health Università degli Studi di Milano Milan Italy

4. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milan Italy

5. Gaetano Pini‐CTO, Parkinson Institute Milan Italy

6. Neuroscience Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana," University of Salerno Baronissi (SA) Italy

7. Department of Neurology "F. Miulli" General Hospital Acquaviva delle Fonti Italy

8. Department of Neurology IRCCS San Raffaele Scientific Institute Milan Italy

9. Neurology Unit and Neurobiorepository and Laboratory of Advanced Biological Markers, Department of Clinical and Experimental Sciences, University of Brescia, and Department of Continuity of Care and Frailty ASST Spedali Civili Brescia Hospital Brescia Italy

10. Department of Translational Medicine, Section of Neurology University of Piemonte Orientale Novara Italy

11. Neurology Unit, Neuromotor and Rehabilitation Department Azienda USL‐IRCCS di Reggio Emilia Reggio Emilia Italy

12. Department of Experimental Medicine, Section of Human Physiology University of Genoa Genoa Italy

13. IRCCS Ospedale Policlinico San Martino—UOC Genetica Medica Genoa Italy

14. Department of Neuroscience and Rehabilitation Azienda Ospedaliera‐Universitaria S. Anna Ferrara Italy

15. Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences Movement Disorders Unit Milan Italy

16. Neurological Department A. Perrino's Hospital Brindisi Italy

17. Department of Advanced Medical and Surgical Sciences University of Campania “Luigi Vanvitelli” Caserta Italy

18. Unit of Neurology, Department of Clinical and Experimental MedicineCenter for Neurodegenerative Diseases—Parkinson's Disease and Movement Disorders University of Pisa Pisa Italy

19. Neurology Unit, Trento Hospital Azienda Provinciale per i Servizi Sanitari (APSS) di Trento Trento Italy

20. Department of Neuroscience "Rita Levi Montalcini" University of Turin Turin Italy

21. Neurology 2 Unit, A.O.U. Città della Salute e della Scienza di Torino Turin Italy

22. Neurology and Stroke Unit Pescara Hospital Pescara Italy

23. Neurorehabilitation Unit IRCCS Centro Neurolesi "Bonino Pulejo," Messina Messina Italy

24. Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy

25. Department of Neurology and Laboratory of Neuroscience Istituto Auxologico Italiano IRCCS Milan Italy

26. Neurology Unit, Rovereto Hospital Azienda Provinciale per i Servizi Sanitari (APSS) di Trento Trento Italy

27. Department of Molecular Medicine University of Pavia Pavia Italy

28. Neurogenetics Research Center IRCCS Mondino Foundation Pavia Italy

29. Department of Neurology IRCCS Humanitas Research Hospital Rozzano Italy

30. Department of Parkinson's Disease Movement Disorders and Brain Injury Rehabilitation, Moriggia Pelascini Hospital Gravedona Italy

31. Parkinson and Movement Disorders Unit, Center for Neurodegenerative Diseases (CENSE), Department of Neuroscience University of Padua Padua Italy

32. Neurology Department ASST Fatebenefratelli Sacco Milan Italy

33. Department of Neurology Santa Maria Hospital Terni Italy

34. Department of Neurorehabilitation Parkinson's Disease Excellence Center, Casa di Cura Villa Margherita via Costacolonna n 1 Arcugnano Vicenza Italy

35. Movement Disorders Center, Neurology Department Perugia General Hospital and University of Perugia Perugia Italy

36. Department of Neuroscience Brotzu Hospital Cagliari Italy

37. Department GF Ingrassia University of Catania Catania Italy

Abstract

AbstractBackgroundFamily history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.ObjectivesWe investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).MethodsA cross‐sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.ResultsFamily history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.ConclusionsfPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.

Publisher

Wiley

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