NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice-Reference-Cited by-同舟云学术

NF-κB and AMPK/PI3K/Akt signaling pathways are involved in the protective effects of Platycodon grandiflorum saponins against acetaminophen-induced acute hepatotoxicity in mice

Published:2018-07-24 Issue:11 Volume:32 Page:2235-2246
ISSN:0951-418X
Container-title:Phytotherapy Research
language:en
Short-container-title:Phytotherapy Research

Author:

Leng Jing¹,Wang Zi¹^ORCID,Fu Cheng-lin¹,Zhang Jing¹,Ren Shen¹,Hu Jun-nan¹,Jiang Shuang¹,Wang Ying-ping¹²,Chen Chen³,Li Wei¹²^ORCID

Affiliation:

1. College of Chinese Medicinal Materials; Jilin Agricultural University; Changchun China

2. National & Local Joint Engineering Research Center for Ginseng Breeding and Development; Changchun China

3. School of Biomedical Sciences; University of Queensland; Brisbane Queensland Australia

Funder

Scientific Research Foundation for the Returned Overseas Chinese Scholars

Program for the Young Top-notch and Innovative Talents of Jilin Agricultural University

Jilin Science & Technology Development Plan

Publisher

Wiley

Subject

Pharmacology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/ptr.6160/fullpdf

Reference49 articles.

1. Akt is upstream and MAPKs are downstream of NF-kappaB in paclitaxel-induced survival signaling events, which are down-regulated by curcumin contributing to their synergism;Bava;The International Journal of Biochemistry & Cell Biology,2011

2. The innate immune response during liver inflammation and metabolic disease;Bieghs;Trends in Immunology,2013

3. Emergency department visits for overdoses of acetaminophen-containing products;Budnitz;American Journal of Preventive Medicine,2011

4. Saponins from the roots of Platycodon grandiflorum ameliorate high fat diet-induced non-alcoholic steatohepatitis;Choi;Biomedicine & Pharmacotherapy,2017

5. Acute hepatocellular drug induced liver injury probably by alfuzosin;Cicek;Case Reports in Urology,2015

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