Pharmacokinetic and brain distribution study of an anti‐glioblastoma agent in mice by HPLC

Pharmacokinetic and brain distribution study of an anti‐glioblastoma agent in mice by HPLC–MS/MS

Published:2022-01-12 Issue:3 Volume:36 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Li Yaxin¹,Dano Raina¹,Li Cathy²,Zhang Wenjing¹,Lathia Justin D.³,Wang Bingcheng⁴,Su Bin¹^ORCID

Affiliation:

1. Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions Cleveland State University Cleveland OH USA

2. Department of Biochemistry Case Western Reserve University Cleveland OH USA

3. Department of Molecular Medicine, Lerner Research Institute Cleveland Clinic, and Case Comprehensive Cancer Center Cleveland OH USA

4. Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Comprehensive Cancer Center Case Western Reserve University School of Medicine Cleveland OH USA

Funder

National Institute of Neurological Disorders and Stroke

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.5310

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3. Hsp-27 and NF-κB pathway is associated with AR/AR-V7 expression in prostate cancer cells

4. Membrane-associated androgen receptor (AR) potentiates its transcriptional activities by activating heat shock protein 27 (HSP27)

5. Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma

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