Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma

Author:

Li Yaxin1,Orahoske Cody M.1,Geldenhuys Werner J.2ORCID,Bhattarai Asmita3,Sabbagh Abboud1,Bobba Viharika1,Salem Fatma M.1,Zhang Wenjing1,Shukla Girish C.3,Lathia Justin D.34,Wang Bingcheng5,Su Bin1ORCID

Affiliation:

1. Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States

2. Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, United States

3. Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Sciences and Health Professions, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States

4. Department of Molecular Medicine, Lerner Research Institute, Cleveland Clinic, and Case Comprehensive Cancer Center, Cleveland, Ohio 44195, United States

5. Rammelkamp Center for Research and Department of Medicine, MetroHealth Campus, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44109, United States

Funder

Cleveland State University

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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