Linear mixed models for association analysis of quantitative traits with next‐generation sequencing data

Author:

Chiu Chi‐yang12,Yuan Fang3,Zhang Bing‐song4,Yuan Ao4,Li Xin4,Fang Hong‐Bin4,Lange Kenneth5,Weeks Daniel E.67ORCID,Wilson Alexander F.2ORCID,Bailey‐Wilson Joan E.2ORCID,Musolf Anthony M.2,Stambolian Dwight8,Lakhal‐Chaieb M'Hamed Lajmi9,Cook Richard J.10,McMahon Francis J.11,Amos Christopher I.12,Xiong Momiao13,Fan Ruzong23ORCID

Affiliation:

1. Division of Biostatistics, Department of Preventive MedicineUniversity of Tennessee Health Science CenterMemphis Tennessee

2. Computational and Statistical Genomics BranchNational Human Genome Research Institute, National Institutes of Health (NIH)Bethesda Maryland

3. Department of Biochemistry and Molecular BiologySchool of Basic Medicine, Kunming Medical UniversityKunming Yunnan China

4. Department of Biostatistics, Bioinformatics, and BiomathematicsGeorgetown University Medical CenterWashington District of Columbia

5. Department of Human GeneticsDavid Geffen School of Medicine, University of CaliforniaLos Angeles California

6. Department of BiostatisticsGraduate School of Public Health, University of PittsburghPittsburgh Pennsylvania

7. Department of Human GeneticsGraduate School of Public Health, University of PittsburghPittsburgh Pennsylvania

8. Department of GeneticsUniversity of PennsylvaniaPhiladelphia Pennsylvania

9. Department de Mathematiques et de StatistiqueUniversite LavalQuebec Canada

10. Department of Statistics and Actuarial ScienceWaterloo Ontario, Quebec Canada

11. Human Genetics Branch and Genetic Basis of Mood and Anxiety Disorders SectionUniversity of Waterloo, National Institute of Mental Health, NIHBethesda Maryland

12. Department of MedicineBaylor College of MedicineHouston Texas

13. Human Genetics CenterUniversity of Texas‐HoustonHouston Texas

Funder

National Human Genome Research Institute

National Institute of Mental Health

Foundation for the National Institutes of Health

National Institutes of Health

Publisher

Wiley

Subject

Genetics (clinical),Epidemiology

Reference51 articles.

1. An integrated map of genetic variation from 1,092 human genomes;Abecasis G. R.;Nature,2012

2. Robust variance‐components approach for assessing linkage in pedigrees;Amos C. I.;American Journal of Human Genetics,1994

3. Population structure and cryptic relatedness in genetic association studies;Astle W.;Statistical Science,2009

4. Genomewide rapid association using mixed model and regression: A fast and simple method for genomewide pedigreebased quantitative trait loci association analysis;Aulchenko Y. S.;Genetics,2007

5. Sequence kernel association test for quantitative traits in family samples;Chen H.;Genetic Epidemiology,2013

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