Nonclinical Pharmacology and Mechanistic Modeling of Antibody-Drug Conjugates in Support of Human Clinical Trials-Reference-Cited by-同舟云学术

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Nonclinical Pharmacology and Mechanistic Modeling of Antibody-Drug Conjugates in Support of Human Clinical Trials

Published:2016-11-03 Issue: Volume: Page:207-243
ISSN:
Container-title:Antibody-Drug Conjugates
language:
Short-container-title:

Author:

Schmidt Brian J.¹,Pan Chin²,Vezina Heather E.¹,Sun Huadong³,Leipold Douglas D.⁴,Gupta Manish¹

Affiliation:

1. Clinical Pharmacology & Pharmacometrics; Bristol-Myers Squibb; Princeton NJ USA

2. Biologics Discovery California; Bristol-Myers Squibb; Redwood City CA USA

3. Pharmaceutical Candidate Optimization; Bristol-Myers Squibb; Princeton NJ USA

4. Department of Preclinical Translational Pharmacokinetics and Pharmacodynamics; Genentech Inc.; South San Francisco CA USA

Publisher

John Wiley & Sons, Inc.

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/9781119060727.ch9/fullpdf

Reference150 articles.

1. Antibody-Drug Conjugates: A Historical Review

2. Comparative clinical pharmacokinetics of antibody-drug conjugates in first-in-human Phase 1 studies;Deslandes;Monoclonal Antibodies,2014

3. Pharmacokinetic considerations for antibody drug conjugates;Lin;Pharmaceutical Research,2012

4. Microtubule inhibitor-based antibody-drug conjugates for cancer therapy;Klute;OncoTargets and Therapy,2014

5. Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics;Bumbaca;The AAPS Journal,2012

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs;Xenobiotica;2024-05-11

2. Virtual Populations for Quantitative Systems Pharmacology Models;Methods in Molecular Biology;2022

3. Pharmacokinetic and Immunological Considerations for Expanding the Therapeutic Window of Next-Generation Antibody–Drug Conjugates;BioDrugs;2018-08-21

4. QSP Toolbox: Computational Implementation of Integrated Workflow Components for Deploying Multi-Scale Mechanistic Models;The AAPS Journal;2017-05-24

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