Use of Physiologically Based Pharmacokinetic Modeling to Identify Physiological and Molecular Characteristics Driving Variability in Axitinib Exposure: A Fresh Approach to Precision Dosing in Oncology-Reference-Cited by-同舟云学术

Use of Physiologically Based Pharmacokinetic Modeling to Identify Physiological and Molecular Characteristics Driving Variability in Axitinib Exposure: A Fresh Approach to Precision Dosing in Oncology

Published:2019-01-11 Issue:6 Volume:59 Page:872-879
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Sorich Michael J.¹,Mutlib Fayzah¹,Dyk Madelé¹,Hopkins Ashley M.¹,Polasek Thomas M.¹²,Marshall Jean‐Claude³,Rodrigues A. David³,Rowland Andrew¹

Affiliation:

1. College of Medicine and Public HealthFlinders University Adelaide Australia

2. Certara Princeton NJ USA

3. Pfizer Worldwide Research and Development Groton CT USA

Funder

National Health and Medical Research Council

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1377

Reference34 articles.

1. Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure

2. In Vitro Characterization of Axitinib Interactions with Human Efflux and Hepatic Uptake Transporters: Implications for Disposition and Drug Interactions

3. Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy?

4. In Vitro Kinetic Characterization of Axitinib Metabolism

5. Clinical Pharmacology of Axitinib

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