Population Pharmacokinetic Analysis of the Cathepsin K Inhibitor Odanacatib: Insights Into Intrinsic and Extrinsic Factor Effects on Exposure in Postmenopausal and Elderly Women
Author:
Affiliation:
1. Cognigen Corporation (a SimulationsPlus Company) Buffalo New York USA
2. Merck & Co., Inc. Kenilworth New Jersey USA
Funder
Merck Sharp & Dohme Corp.
Merck & Co., Inc., Kenilworth, NJ, USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1606
Reference27 articles.
1. Inhibition of Cathepsin K for Treatment of Osteoporosis
2. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K
3. Merck & Co. drops osteoporosis drug odanacatib;Mullard A;Nat Rev Drug Discov,2016
4. Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis
5. Odanacatib, a selective cathepsin K inhibitor to treat osteoporosis: safety, tolerability, pharmacokinetics and pharmacodynamics - results from single oral dose studies in healthy volunteers
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