The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K-Reference-Cited by-同舟云学术

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Published:2008-02 Issue:3 Volume:18 Page:923-928
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Gauthier Jacques Yves,Chauret Nathalie,Cromlish Wanda,Desmarais Sylvie,Duong Le T.,Falgueyret Jean-Pierre,Kimmel Donald B.,Lamontagne Sonia,Léger Serge,LeRiche Tammy,Li Chun Sing,Massé Frédéric,McKay Daniel J.,Nicoll-Griffith Deborah A.,Oballa Renata M.,Palmer James T.,Percival M. David,Riendeau Denis,Robichaud Joel,Rodan Gideon A.,Rodan Sevgi B.,Seto Carmai,Thérien Michel,Truong Vouy-Linh,Venuti Michael C.,Wesolowski Gregg,Young Robert N.,Zamboni Robert,Black W. Cameron

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference23 articles.

1. Inhibition of the Cysteine Protease Cathepsin K (EC 3.4.22.38)

2. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

3. P2–P3 conformationally constrained ketoamide-based inhibitors of cathepsin K

4. A highly potent inhibitor of cathepsin K (relacatib) reduces biomarkers of bone resorption both in vitro and in an acute model of elevated bone turnover in vivo in monkeys

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