Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress

Author:

García-Lara Lucia1,Pérez-Severiano Francisca2,González-Esquivel Dinora2,Elizondo Guillermo3,Segovia José1

Affiliation:

1. Departamento de Fisiología; Biofísica; y Neurociencias; Centro de Investigación y de Estudios Avanzados del IPN; México D.F. México

2. Departamento de Neuroquímica; Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez; México D.F. México

3. Departamento de Biología Celular; Centro de Investigación y de Estudios Avanzados del IPN; México D.F. México

Funder

CONACyT

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience

Reference66 articles.

1. Abedi Mukutenga P Taghzouti K Bengelloun WA. 2012 Effects of bilateral electrolytic lesions of the dorsomedial striatum on motor behavior and instrumental learning in rats Basic Clin Neurosci 3 52 59

2. Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine;Alexander;Neuroscience,2013

3. The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease;Amaral;J Mol Med,2013

4. Molecular strategies for the treatment of Huntington's disease;Arregui;Curr Pharmacogenomics,2004

5. Adenoviral astrocyte-specific expression of BDNF in the striata of mice transgenic for Huntington's disease delays the onset of the motor phenotype;Arregui;Cell Mol Neurobiol,2011

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