The effect of statin medication on the incidence of oral squamous cell carcinoma among betel‐nut chewers-Reference-Cited by-同舟云学术

The effect of statin medication on the incidence of oral squamous cell carcinoma among betel‐nut chewers

Published:2023-03-28 Issue:6 Volume:45 Page:1455-1467
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Huang Chun‐Chi¹,Chen Wan‐Ming²³,Shia Ben‐Chang²³,Chen Mingchih²³,Wu Szu‐Yuan²³⁴⁵⁶^ORCID

Affiliation:

1. Department of Otorhinolaryngology Lo‐Hsu Medical Foundation, Lotung Poh‐Ai Hospital Yilan Taiwan

2. Graduate Institute of Business Administration, College of Management Fu Jen Catholic University Taipei Taiwan

3. Artificial Intelligence Development Center Fu Jen Catholic University Taipei Taiwan

4. Department of Food Nutrition and Health Biotechnology, College of Medical and Health Science Asia University Taichung Taiwan

5. Division of Radiation Oncology Lo‐Hsu Medical Foundation, Lotung Poh‐Ai Hospital Yilan Taiwan

6. Big Data Center Lo‐Hsu Medical Foundation, Lotung Poh‐Ai Hospital Yilan Taiwan

Abstract

AbstractBackgroundThis study examines the relationship between statin use and oral cancer squamous cell carcinoma (OCSCC) risk in a cohort of 47 942 betel nut chewers.MethodsThe study used individual 1:1 matching and propensity score matching to compare statin users and nonusers.ResultsThe incidence rate of OCSCC was significantly lower in statin users compared to nonusers (17.12 vs. 26.75 per 10 000 person‐years), yielding an incidence rate ratio of 0.64. After adjusting for confounders, statin use was associated with a reduced risk of OCSCC (adjusted hazard ratio: 0.61; 95% confidence interval: 0.52–0.71). A dose–response relationship was observed, with a significant reduction in OCSCC incidence when the cumulative defined daily dose of statin use was equal to or greater than Q3. The risk of OCSCC was lower among users of both hydrophilic and lipophilic statins.ConclusionThis study provides evidence that statin use is associated with a reduced risk of OCSCC in betel nut chewers.

Publisher

Wiley

Subject

Otorhinolaryngology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27358

Reference53 articles.

1. Predictors of betel quid chewing behavior and cessation patterns in Taiwan aborigines

2. Betel Nut: A Common Drug Used by Naturalized Citizens From India, Far East Asia, and the South Pacific Islands

3. Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan

4. Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors

5. Cancer risks from betel quid chewing beyond oral cancer: a multiple-site carcinogen when acting with smoking

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