Affiliation:
1. Medical School, Pingdingshan University, Pingdingshan 467000, China
2. Affiliated Stomatology Hospital, Pingdingshan University, Pingdingshan 467000, China
Abstract
Oral cancer is a common malignancy with a high mortality rate. Although surgery is the best treatment option for patients with cancer, this approach is ineffective for advanced metastases. Molecular agents are irreplaceable in preventing and treating distant metastases. This review aims to summarise the molecular agents used for the treatment of oral cancer in the last decade and describe their sources and curative effects. These agents are classified into phenols, isothiocyanates, anthraquinones, statins, flavonoids, terpenoids, and steroids. The mechanisms of action of these agents include regulating the expression of cell signalling pathways and related proteases to affect the proliferation, autophagy, migration, apoptosis, and other biological aspects of oral cancer cells. This paper may serve as a reference for subsequent studies on the treatment of oral cancer.
Funder
Science and Technology Public Relations Project of Henan Province
Key scientific research project plan of colleges and universities in Henan Province
Natural Science Foundation of Henan
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