Glycogen synthase kinase-3 controls IL-10 expression in CD4+ effector T-cell subsets through epigenetic modification of the IL-10 promoter

Author:

Hill Elaine V.1,Ng T. H. Sky1,Burton Bronwen R.1,Oakley Charly M.1,Malik Karim2,Wraith David C.1

Affiliation:

1. School of Cellular and Molecular Medicine; University of Bristol; Bristol UK

2. Cancer Epigenetics Lab; School of Cellular and Molecular Medicine; University of Bristol; Bristol UK

Funder

Wellcome Trust Program

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference63 articles.

1. The regulation of IL-10 production by immune cells;Saraiva;Nat. Rev. Immunol.,2010

2. Regulation of adaptive immunity; the role of interleukin-10;Ng;Front Immunol.,2013

3. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha;Gazzinelli;J. Immunol.,1996

4. Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells;Suri-Payer;J. Autoimmun.,2001

5. Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice;Hata;J. Clin. Invest.,2004

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