Chicken Glycogen Synthase Kinase 3β Suppresses Innate Immune Responses and Enhances Avian Leukosis Virus Replication in DF-1 Cells-Reference-Cited by-同舟云学术

Chicken Glycogen Synthase Kinase 3β Suppresses Innate Immune Responses and Enhances Avian Leukosis Virus Replication in DF-1 Cells

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Cui Zhouhao¹²,Weng Bei¹²,Yao Yongxiu³^ORCID,Shao Hongxia¹²⁴,Ye Jianqiang¹²⁵^ORCID,Qin Aijian¹²⁵^ORCID,Qian Kun¹²⁴⁵^ORCID

Affiliation:

1. Ministry of Education Key Laboratory for Avian Preventive Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

2. Jiangsu Key Laboratory of Preventive Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

3. The Pirbright Institute & UK-China Centre of Excellence for Research on Avian Diseases, Pirbright, Surrey, United Kingdom

4. The International Joint Laboratory for Cooperation in Agriculture and Agricultural Product Safety, Ministry of Education, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

5. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China

Abstract

GSK3β regulates many life activities in mammals. Recent studies revealed that chGSK3β was involved in regulating antiviral innate immunity in DF-1 cells and also could positively regulate ALV-J replication. These results provide new insights into the biofunction of chGSK3β and the virus-host interactions of ALV-J. In addition, this study provides a basis for further research on the function of GSK3 in poultry.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

UKRI | Biotechnology and Biological Sciences Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05235-22

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