Beyond the single average tumor: Understanding IO combinations using a clinical QSP model that incorporates heterogeneity in patient response
Author:
Affiliation:
1. Vantage Research LLC Delaware City Delaware USA
2. Vantage Research Pvt. Ltd Chennai India
3. Merck & Co., Inc. Kenilworth New Jersey USA
Funder
Merck Sharp and Dohme
Publisher
Wiley
Subject
Pharmacology (medical),Modelling and Simulation
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/psp4.12637
Reference24 articles.
1. Quantitative Systems Pharmacology Approaches for Immuno‐Oncology: Adding Virtual Patients to the Development Paradigm
2. Quantitative Mechanistic Modeling in Support of Pharmacological Therapeutics Development in Immuno-Oncology
3. ToppB KumarR MayawalaK deAlwisD HellmannM SnyderA. "Inter‐tumoral heterogeneity of progressive disease in melanoma patients treated with pembrolizumab " inCancer Res (AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact) Virtual September 17–18 2020.
4. Using an IO QSP model to re‐define efficacy, discontinuation criteria, and biomarker analysis;Channavazzala M;ACoP11,2020
5. Pembrolizumab versus Ipilimumab in Advanced Melanoma
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Practical QSP application from the preclinical phase to enhance the probability of clinical success: Insights from case studies in oncology;Drug Metabolism and Pharmacokinetics;2024-06
2. Realizing the Promise of Project Optimus: Challenges and Emerging Opportunities for Dose Optimization in Oncology Drug Development;CPT: Pharmacometrics & Systems Pharmacology;2023-11-15
3. A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition;Science Advances;2023-06-30
4. Incorporating lesion-to-lesion heterogeneity into early oncology decision making;Frontiers in Immunology;2023-06-07
5. Sloppiness: Fundamental study, new formalism and its application in model assessment;PLOS ONE;2023-03-08
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3