A proof-of-concept clinical trial design combined with dose-ranging exploration
Author:
Affiliation:
1. Pfizer, Inc.; Groton Connecticut USA
2. Boehringer-Ingelheim Pharmaceuticals, Inc.; Ridgefield Connecticut USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology,Statistics and Probability
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/pst.1525/fullpdf
Reference18 articles.
1. Statistical Analysis of Designed Experiments
2. Gatekeeping strategies for clinical trials that do not require all primary effects to be significant;Dmitrienko;Statistics in Medicine,2003
3. Analysis of Dose–Response Studies—Emax Model
4. Hypothesis testing and Bayesian estimation using a sigmoid Emax model applied to sparse dose-response designs;Thomas;Journal of Biopharmaceutical Statistics,2006
5. Combining multiple comparisons and modeling techniques in dose-response studies;Bretz;Biometrics,2005
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