Fragment‐Based Discovery of Non‐bisphosphonate Binders ofTrypanosoma bruceiFarnesyl Pyrophosphate Synthase-Reference-Cited by-同舟云学术

Fragment‐Based Discovery of Non‐bisphosphonate Binders ofTrypanosoma bruceiFarnesyl Pyrophosphate Synthase

Published:2020-07-13 Issue:21 Volume:21 Page:3096-3111
ISSN:1439-4227
Container-title:ChemBioChem
language:en
Short-container-title:ChemBioChem

Author:

Münzker Lena¹^ORCID,Petrick Joy Kristin¹^ORCID,Schleberger Christian¹^ORCID,Clavel Damien²^ORCID,Cornaciu Irina²³^ORCID,Wilcken Rainer¹^ORCID,Márquez José A.²³^ORCID,Klebe Gerhard⁴^ORCID,Marzinzik Andreas¹^ORCID,Jahnke Wolfgang¹^ORCID

Affiliation:

1. Novartis Institutes for Biomedical Research Novartis Campus 4002 Basel Switzerland

2. EMBL Grenoble 71 Avenue des Martyrs, CS 90181 38042 Grenoble, CEDEX 9 France

3. ALPX 71 Avenue des Martyrs, CS 90181 38042 Grenoble, CEDEX 9 France

4. Institut für Pharmazie Philipps-Universität Marburg Marbacher Weg 6 35032 Marburg Germany

Funder

H2020 Marie Skłodowska-Curie Actions

H2020 Research Infrastructures

Publisher

Wiley

Subject

Organic Chemistry,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbic.202000246

Reference73 articles.

1. WHO Technical Report Series 984 World Health Organization Geneva Switzerland 2013.

2. Monitoring the elimination of human African trypanosomiasis: Update to 2014

3. Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

4. Determination of an Optimal Dosing Regimen for Fexinidazole, a Novel Oral Drug for the Treatment of Human African Trypanosomiasis: First-in-Human Studies

5. Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial

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