Pyroptosis and inflammasomes in cancer and inflammation

Author:

Wang Jie‐Lin12,Hua Sheng‐Ni3ORCID,Bao Hai‐Juan12,Yuan Jing12,Zhao Yang12ORCID,Chen Shuo12

Affiliation:

1. Department of Obstetrics and Gynecology Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China

2. Department of Gynecologic Oncology Research Office Guangzhou Key Laboratory of Targeted Therapy for Gynecologic Oncology Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical University Guangzhou China

3. Department of Radiation Oncology Zhuhai People s Hospital Zhuhai Hospital Affiliated with Jinan University Zhuhai China

Abstract

AbstractNonprogrammed cell death (NPCD) and programmed cell death (PCD) are two types of cell death. Cell death is significantly linked to tumor development, medication resistance, cancer recurrence, and metastatic dissemination. Therefore, a comprehensive understanding of cell death is essential for the treatment of cancer. Pyroptosis is a kind of PCD distinct from autophagy and apoptosis in terms of the structure and function of cells. The defining features of pyroptosis include the release of an inflammatory cascade reaction and the expulsion of lysosomes, inflammatory mediators, and other cellular substances from within the cell. Additionally, it displays variations in osmotic pressure both within and outside the cell. Pyroptosis, as evidenced by a growing body of research, is critical for controlling the development of inflammatory diseases and cancer. In this paper, we reviewed the current level of knowledge on the mechanism of pyroptosis and inflammasomes and their connection to cancer and inflammatory diseases. This article presents a theoretical framework for investigating the potential of therapeutic targets in cancer and inflammatory diseases, overcoming medication resistance, establishing nanomedicines associated with pyroptosis, and developing risk prediction models in refractory cancer. Given the link between pyroptosis and the emergence of cancer and inflammatory diseases, pyroptosis‐targeted treatments may be a cutting‐edge treatment strategy.

Funder

National Natural Science Foundation of China

Project for Key Medicine Discipline Construction of Guangzhou Municipality

Publisher

Wiley

Subject

Cell Biology,Biochemistry (medical),Genetics (clinical),Computer Science Applications,Drug Discovery,Genetics,Oncology,Immunology and Allergy

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