Can inflammatory markers in induced sputum be used to detect phenotypes and endotypes of pediatric severe therapy-resistant asthma?

Author:

Eller Miriam C. N.1ORCID,Vergani Karina P.1,Saraiva-Romanholo Beatriz M.2,Antonangelo Leila3,Leone Claudio4,Rodrigues Joaquim C.5

Affiliation:

1. Instituto da Criança, Hospital das Clínicas, School of Medicine; University of São Paulo; São Paulo Brazil

2. School of Medicine; University of São Paulo (FMUSP) and University of City of São Paulo (UNICID); São Paulo Brazil

3. Clinical Laboratory; Pathology Department; Hospital das Clínicas; University of Sao Paulo; São Paulo Brazil

4. Maternal and Child Health Department; School of Public Health; University of São Paulo; São Paulo Brazil

5. Department of Pediatric; Pediatric Pulmonology Unit, Instituto da Criança, Hospital das Clínicas, School of Medicine; University of São Paulo; São Paulo Brazil

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine,Pediatrics, Perinatology and Child Health

Reference39 articles.

1. Identification of asthma phenotypes using cluster analysis in the severe asthma research program;Moore;Am J Respir Crit Care Med,2010

2. International ERS/ATS guidelines on definition, evaluation, and treatment of severe asthma;Chung;Eur Respir J,2014

3. Severe asthma: how can we differentiate phenotypes;Louis;Swiss Med Wkly,2009

4. Difficult/therapy-resistant asthma: the need for an integrated approach to define clinical phenotypes, evaluate risk factors, understand pathophysiology and find novel therapies. ERS Task Force on Difficult/Therapy-Resistant Asthma. European Respiratory Society;Chung;Eur Respir J,1999

5. Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI);Bel;Thorax,2011

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