A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma-Reference-Cited by-同舟云学术

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A phase II study of clinical activity of SCH 717454 (robatumumab) in patients with relapsed osteosarcoma and Ewing sarcoma

Published:2016-06-30 Issue:10 Volume:63 Page:1761-1770
ISSN:1545-5009
Container-title:Pediatric Blood & Cancer
language:en
Short-container-title:Pediatr Blood Cancer

Author:

Anderson Peter M.¹,Bielack Stefan S.²,Gorlick Richard G.³,Skubitz Keith⁴,Daw Najat C.¹,Herzog Cynthia E.¹,Monge Odd R.⁵,Lassaletta Alvaro⁶,Boldrini Erica⁷,Pápai Zsuzanna⁸,Rubino Joseph⁹,Pathiraja Kumudu⁹,Hille Darcy A.⁹,Ayers Mark⁹,Yao Siu‐Long⁹,Nebozhyn Michael⁹,Lu Brian⁹,Mauro David⁹

Affiliation:

1. MD Anderson Cancer Center Houston Texas

2. Klinikum Stuttgart–Olgahospital Stuttgart Germany

3. Montefiore Medical Center Bronx New York

4. University of Minnesota Minneapolis Minnesota

5. Haukeland University Hospital Bergen Norway

6. Hospital Infantil Universitario Niño Jesus Madrid Spain

7. Barretos Cancer Center Barretos Brazil

8. Military Hospital‐State Health Centre Budapest Hungary

9. Merck & Co., Inc Kenilworth New Jersey

Funder

Merck

Publisher

Wiley

Subject

Oncology,Hematology,Pediatrics, Perinatology and Child Health

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/pbc.26087

Reference50 articles.

1. Ewing's sarcoma

2. IGF-1R/MDM2 Relationship Confers Enhanced Sensitivity to RITA in Ewing Sarcoma Cells

3. Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program

4. Development of IGF-IR inhibitors in pediatric sarcomas

5. Insulin-like growth factor type 1 (IGF-1) and IGF binding protein-3 in patients with Ewing sarcoma family of tumors

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