Comparison of Plasma and Brain Exposure Levels of Bis‐pyridinium Oximes KR‐22839 and KR‐26256 with Asoxime and Obidoxime in Mice-Reference-Cited by-同舟云学术

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Comparison of Plasma and Brain Exposure Levels of Bis‐pyridinium Oximes KR‐22839 and KR‐26256 with Asoxime and Obidoxime in Mice

Published:2018-12-13 Issue: Volume: Page:
ISSN:1229-5949
Container-title:Bulletin of the Korean Chemical Society
language:en
Short-container-title:Bull. Korean Chem. Soc.

Author:

Lee Hyun Myung¹²,Ahn Sunjoo¹,Lee Ha‐Yeon¹,Im Jae Min¹,Cho Sung Hee¹,Kuca Kamil³,Musilek Kamil³⁴,Han Soo Bong¹²,Hur Gyeunghaeng⁵,Jung Young‐Sik¹²

Affiliation:

1. Division of Bio and Drug DiscoveryKorea Research Institute of Chemical Technology Daejeon 34114 Republic of Korea

2. Department of Medicinal and Pharmaceutical ChemistryUniversity of Science and Technology Daejeon 34113 Republic of Korea

3. Faculty of Science, Department of ChemistryUniversity of Hradec Kralove Hradec Kralove Czech Republic

4. University Hospital Hradec KraloveBiomedical Research Centre Czech Republic

5. Agency for Defense Development Daejeon 34186 Republic of Korea

Funder

Ministerstvo Školství, Mládeže a Tělovýchovy

Publisher

Wiley

Subject

General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bkcs.11632

Reference14 articles.

1. Organophosphate poisoning

2. The Pharmacological Basis of Therapeutics 1996 McGraw Hill New York P. Taylor J. G. Hardman L. E. Limbird Anticholinesterase agents 161

3. Entry of Oximes into the Brain: A Review

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1. Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase;Bioorganic & Medicinal Chemistry Letters;2023-11

2. Dicationic pyridinium salts as new organic ionics: Changes in solid-state phases and thermal/electrochemical properties;Journal of Industrial and Engineering Chemistry;2021-12

3. Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates;Journal of Enzyme Inhibition and Medicinal Chemistry;2021-01-01

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