Fluorescence lifetime imaging of DAPI-stained nuclei as a novel diagnostic tool for the detection and classification of B-cell chronic lymphocytic leukemia

Author:

Yahav Gilad1,Hirshberg Abraham2,Salomon Ophira3,Amariglio Ninette4,Trakhtenbrot Luba4,Fixler Dror1

Affiliation:

1. Faculty of Engineering and Institute of Nanotechnology and Advanced Materials; Bar Ilan University; Ramat Gan Israel

2. Department of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldschleger School of Dental Medicine; Tel Aviv University; Tel Aviv Israel

3. Thrombosis Unit, Sheba Medical Center and Sackler Faculty of Medicine; Tel Aviv University; Tel Aviv Israel

4. Laboratory of Hematology; Sheba Medical Center; Ramat Gan Israel

Funder

Israel Cancer Association

Publisher

Wiley

Subject

Cell Biology,Histology,Pathology and Forensic Medicine

Reference50 articles.

1. A nuclear-envelope bridge positions nuclei and moves chromosomes;Starr;J Cell Sci,2009

2. Variations of the spatial fluorescence distribution in ABL gene chromatin domains measured in blood cell nuclei by SMI microscopy after COMBO-FISH labelling;Grossmann;Microsc Sci Technol Appl Edu,2010

3. Nuclear structure in cancer cells;Zink;Nat Rev Cancer,2004

4. The radial nuclear positioning of genes correlates with features of megabase-sized chromatin domains;Kölbl;Chromosome Res,2012

5. Comparison of triple helical COMBO-FISH and standard FISH by means of quantitative microscopic image analysis of abl/bcr positions in cell nuclei;Schwarz-Finsterle;J Biochem Biophys Methods,2007

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