An Application of Machine Learning in Pharmacovigilance: Estimating Likely Patient Genotype From Phenotypical Manifestations of Fluoropyrimidine Toxicity-Reference-Cited by-同舟云学术

An Application of Machine Learning in Pharmacovigilance: Estimating Likely Patient Genotype From Phenotypical Manifestations of Fluoropyrimidine Toxicity

Published:2020-02-27 Issue:4 Volume:107 Page:944-947
ISSN:0009-9236
Container-title:Clinical Pharmacology & Therapeutics
language:en
Short-container-title:Clin. Pharmacol. Ther.

Author:

Correia Pinheiro Luis¹,Durand Julie¹,Dogné Jean‐Michel²³

Affiliation:

1. European Medicines Agency Amsterdam The Netherlands

2. University of Namur Namur Belgium

3. Belgian Federal Agency for Medicines and Health Products Brussels Belgium

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1789

Reference16 articles.

1. Chemotherapy of human solid tumors with 5-fluorouracil

2. 5-Fluorouracil Pharmacokinetics: Causes for Variability and Strategies for Modulation in Cancer Chemotherapy

3. Cost Implications of Reactive Versus Prospective Testing for Dihydropyrimidine Dehydrogenase Deficiency in Patients With Colorectal Cancer: A Single-Institution Experience

4. Dihydropyrimidine Dehydrogenase Deficiency, a Pharmacogenetic Syndrome Associated with Potentially Life-Threatening Toxicity Following 5-Fluorouracil Administration

5. Genetic and Rare Diseases Information Center Dihydropyrimidine dehydrogenase deficiency. Accessed September 15 2019.

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The future of medicine: an outline attempt using state-of-the-art business and scientific trends;Frontiers in Medicine;2024-08-07

2. Artificial intelligence for optimizing benefits and minimizing risks of pharmacological therapies: challenges and opportunities;Frontiers in Drug Safety and Regulation;2024-03-18

3. Gene Regulatory Network-Classifier: Gene Regulatory Network-Based Classifier and Its Applications to Gastric Cancer Drug (5-Fluorouracil) Marker Identification;Journal of Computational Biology;2023-02-01

4. Artificial intelligence in pharmacovigilance: A regulatory perspective on explainability;Pharmacoepidemiology and Drug Safety;2022-09-08

5. The Use of Artificial Intelligence in Pharmacovigilance: A Systematic Review of the Literature;Pharmaceutical Medicine;2022-07-29