Why Has Model-Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future

Author:

Darwich A S1,Ogungbenro K1,Vinks A A23,Powell J R4,Reny J-L56,Marsousi N7,Daali Y57,Fairman D8,Cook J9,Lesko L J10,McCune J S11,Knibbe C A J12,de Wildt S N1314,Leeder J S1516,Neely M17,Zuppa A F18,Vicini P19,Aarons L1,Johnson T N20,Boiani J21,Rostami-Hodjegan A121

Affiliation:

1. Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry; University of Manchester; Manchester UK

2. Cincinnati Children's Hospital Medical Center; Cincinnati Ohio USA

3. Department of Pediatrics; University of Cincinnati School of medicine; Cincinnati Ohio USA

4. Eshelman School of Pharmacy; University of North Carolina; Chapel Hill North Carolina USA

5. Geneva Platelet Group, School of Medicine; University of Geneva; Geneva Switzerland

6. Department of Internal Medicine, Rehabilitation and Geriatrics; Geneva University Hospitals; Geneva Switzerland

7. Clinical Pharmacology and Toxicology; Geneva University Hospitals; Geneva Switzerland

8. Clinical Pharmacology Modeling and Simulation, GSK Stevenage; UK

9. Clinical Pharmacology, Pfizer Inc; Groton Connecticut USA

10. Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology; University of Florida at Lake Nona (Orlando); Orlando Florida USA

11. University of Washington Department of Pharmaceutics and Fred Hitchinson Cancer Research Center Clinical Research Division; Seattle Washington USA

12. Department of Clinical Pharmacy, St. Antonius Hospital, Nieuwegein, the Netherlands and Division of Pharmacology, Leiden Academic Centre for Drug Research; Leiden University; the Netherlands

13. Department of Pharmacology and Toxicology; Radboud University; Nijmegen the Netherlands

14. Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children's Hospital; Rotterdam the Netherlands

15. Division of Pediatric Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics; Kansas City Missouri USA

16. Department of Pharmacology; University of Missouri-Kansas City; Kansas City Missouri USA

17. University of Southern California and the Children's Hospital of Los Angeles; Los Angeles California USA

18. Children's Hospital of Philadelphia; Philadelphia Pennsylvania USA

19. Clinical Pharmacology, Pharmacometrics and DMPK, MedImmune; Cambridge UK

20. Certara, Blades Enterprise Centre; Sheffield UK

21. Epstein Becker & Green; Washington DC USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference75 articles.

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2. AGenentech TAMIFLU(R) (Oseltamivir Phosphate) Capsules, for Oral Suspension: Highlights of Prescribing Information

3. N. Developing a paediatric drug formulary for the Netherlands;Zanden;Arch. Dis. Child.,2016

4. NKFK Kinderformularium - Vancomycine https://www.kinderformularium.nl/geneesmiddel/337/vancomycine 2016

5. ARoche CYTOVENE(R)-IV (ganciclovir sodium for injection): Prescribing information

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