Methyltransferases do not work by compression, cratic, or desolvation effects, but by electrostatic preorganization
Author:
Affiliation:
1. Department of Chemistry; University of Southern California; SGM 418 Los Angeles California 90089
2. Faculdade de Biotecnologia e Laboratório de Planejamento e Desenvolvimento de Fármacos, Universidade Federal do Pará; 66075-110 Belém PA Brazil
Funder
NIH
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Programa Ciência sem Fronteira
Publisher
Wiley
Subject
Molecular Biology,Biochemistry,Structural Biology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/prot.24717/fullpdf
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5. Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson's disease and L-DOPA treatment;Espinoza;CNS Neurol Disord Drug Targets,2012
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