Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography-Reference-Cited by-同舟云学术

Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography

Published:2021-05-27 Issue:8 Volume:118 Page:2923-2933
ISSN:0006-3592
Container-title:Biotechnology and Bioengineering
language:en
Short-container-title:Biotech & Bioengineering

Author:

Saleh David¹²^ORCID,Hess Rudger¹²,Ahlers‐Hesse Michelle¹,Beckert Nicole³,Schönberger Markus¹,Rischawy Federico¹²,Wang Gang¹,Bauer Joschka³,Blech Michaela³,Kluters Simon¹^ORCID,Studts Joey¹,Hubbuch Jürgen²

Affiliation:

1. Late Stage DSP Development Boehringer Ingelheim Biberach Germany

2. Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering Karlsruhe Institute of Technology (KIT) Karlsruhe Germany

3. Pharmaceutical Development Biologics Boehringer Ingelheim Biberach Germany

Publisher

Wiley

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bit.27798

Reference62 articles.

1. Predicting Antibody Developability Profiles Through Early Stage Discovery Screening

2. A molecular modeling based method to predict elution behavior and binding patches of proteins in multimodal chromatography

3. Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

4. High-throughput micro-scale cultivations and chromatography modeling: Powerful tools for integrated process development

5. Prediction of lab and manufacturing scale chromatography performance using mini-columns and mechanistic modeling

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