Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain-Reference-Cited by-同舟云学术

Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain

Published:2020-01-01 Issue:1 Volume:12 Page:
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Bauer Joschka¹,Mathias Sven²³,Kube Sebastian¹,Otte Kerstin²,Garidel Patrick¹,Gamer Martin³,Blech Michaela¹,Fischer Simon⁴,Karow-Zwick Anne R¹

Affiliation:

1. Early Stage Pharmaceutical Development, Pharmaceutical Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/Riss, Germany

2. Institute of Applied Biotechnology, University of Applied Sciences Biberach, Biberach/Riss, Germany

3. Early Stage Bioprocess Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/Riss, Germany

4. Cell Line Development, Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach/Riss, Germany

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/19420862.2020.1787121

Reference72 articles.

1. Discovery and development of biopharmaceuticals: current issues

2. Innovating by Developing New Uses of Already-Approved Drugs: Trends in the Marketing Approval of Supplemental Indications

3. Pharma Success in Product Development—Does Biotechnology Change the Paradigm in Product Development and Attrition

4. Aggregation risk prediction for antibodies and its application to biotherapeutic development

5. Advances in recombinant antibody manufacturing

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