Affiliation:
1. Department of Bioengineering Imperial College London South Kensington London SW7 2AZ UK
2. Cancer Research UK Convergence Science Centre London SW7 2AZ UK
Abstract
AbstractMicrovascular networks are essential for the efficient transport of nutrients, waste products, and drugs throughout the body. Wire‐templating is an accessible method for generating laboratory models of these blood vessel networks, but it has difficulty fabricating microchannels with diameters of ten microns and narrower, a requirement for modeling human capillaries. This study describes a suite of surface modification techniques to selectively control the interactions amongst wires, hydrogels, and world‐to‐chip interfaces. This wire templating method enables the fabrication of perfusable hydrogel‐based rounded cross‐section capillary‐scale networks whose diameters controllably narrow at bifurcations down to 6.1 ± 0.3 microns in diameter. Due to its low cost, accessibility, and compatibility with a wide range of common hydrogels of tunable stiffnesses such as collagen, this technique may increase the fidelity of experimental models of capillary networks for the study of human health and disease.
Funder
Cancer Research UK
Imperial College London
Engineering and Physical Sciences Research Council
Rotary Foundation
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
1 articles.
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