Histidine‐Mediated Synthesis of Chiral Cobalt Oxide Nanoparticles for Enantiomeric Discrimination and Quantification

Author:

Liu Xing1,Du Yanli1,Wang Shenli2,Huang Yu1,Tian Yongzhi1,García‐Lojo Daniel34ORCID,Pérez‐Juste Ignacio4,Pérez‐Juste Jorge34ORCID,Pastoriza‐Santos Isabel34ORCID,Zheng Guangchao1

Affiliation:

1. School of Physics and Microelectronics Zhengzhou University Zhengzhou 450001 P. R. China

2. School of Food Science and Engineering Henan University of Technology Lianhua Road 100 Zhengzhou 450001 P. R. China

3. CINBIO Universidade de Vigo Campus Universitario As Lagoas Marcosende Vigo 36310 Spain

4. Departamento de Química Física Universidade de Vigo Campus Universitario As Lagoas Marcosende Vigo 36310 Spain

Abstract

AbstractChiral transition metal oxide nanoparticles (CTMOs) are attracting a lot of attention due to their fascinating properties. Nevertheless, elucidating the chirality induction mechanism often remains a major challenge. Herein, the synthesis of chiral cobalt oxide nanoparticles mediated by histidine (Co3O4@L‐His and Co3O4@D‐His for nanoparticles synthesized in the presence of L‐ and D‐histidine, respectively) is investigated. Interestingly, these CTMOs exhibit remarkable and tunable chiroptical properties. Their analysis by x‐ray photoelectron, Fourier transform infrared, and ultraviolet‐visible absorption spectroscopy indicates that the ratio of Co2+/Co3+ and their interactions with the imidazole groups of histidine are behind their chiral properties. In addition, the use of chiral Co3O4 nanoparticles for the development of sensitive, rapid, and enantioselective circular dichroism‐based sensors is demonstrated, allowing direct molecular detection and discrimination between cysteine or penicillamine enantiomers. The circular dichroism response of the chiral Co3O4 exhibits a limit of detection and discrimination of cysteine and penicillamine enantiomers as low as 10 µm. Theoretical calculations suggest that the ligand exchange and the coexistence of both species adsorbed on the oxide surface are responsible for the enantiomeric discrimination. This research will enrich the synthetic approaches to obtain CTMOs and enable the extension of the applications and the discovery of new chiroptical properties.

Funder

National Natural Science Foundation of China

European Regional Development Fund

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

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