Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo-Reference-Cited by-同舟云学术

Mechanistic Studies of an Automated Lipid Nanoparticle Reveal Critical Pharmaceutical Properties Associated with Enhanced mRNA Functional Delivery In Vitro and In Vivo

Published:2021-12-16 Issue: Volume: Page:2105832
ISSN:1613-6810
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language:en
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Author:

Cui Lili¹^ORCID,Hunter Morag R.¹,Sonzini Silvia¹,Pereira Sara¹,Romanelli Steven M.²,Liu Kai³,Li Weimin¹,Liang Lihuan⁴,Yang Bin¹,Mahmoudi Najet⁵,Desai Arpan S.¹

Affiliation:

1. Advanced Drug Delivery Pharmaceutical Sciences BioPharmaceuticals R&D AstraZeneca Cambridge CB21 6GH UK

2. University of Michigan Medical School Department of Molecular & Integrative Physiology Ann Arbor MI 48109‐5624 USA

3. Advanced Drug Delivery Pharmaceutical Sciences BioPharmaceuticals R&D AstraZeneca Gothenburg 43183 Sweden

4. Bioscience Renal Research and Early Development Cardiovascular Renal & Metabolism (CVRM) BioPharmaceuticals R&D AstraZeneca Cambridge CB21 6GH UK

5. Rutherford Appleton Laboratory ISIS Facility Science and Technology Facilities Council Didcot OX11 0QX UK

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.202105832

Reference80 articles.

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3. mRNA vaccines — a new era in vaccinology

4. Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

5. WHO “Draft landscape of COVID‐19 candidate vaccines ”2020.

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