Room Temperature Synthesis Mediated Porphyrinic NanoMOF Enables Benchmark Electrochemical Biosensing

Abstract

AbstractLeveraging size effects, nanoparticles of metal‐organic frameworks, nanoMOFs, have recently gained traction, amplifying their scopes in electrochemical sensing. However, their synthesis, especially under eco‐friendly ambient conditions remains an unmet challenge. Herein, an ambient and fast secondary building unit (SBU)‐assisted synthesis (SAS) route to afford a prototypal porphyrinic MOF, Fe‐MOF‐525 is introduced. Albeit the benign room temperature conditions, Fe‐MOF‐525(SAS) nanocrystallites obtained are of ≈30 nm size, relatively smaller than the ones conventional solvothermal methods elicit. Integrating Fe‐MOF‐525(SAS) as a thin film on a conductive indium tin oxide (ITO) surface affords Fe‐MOF‐525(SAS)/ITO, an electrochemical biosensor. Synergistic confluence of modular MOF composition, analyte‐specific redox metalloporphyrin sites, and crystal downsizing contribute to its benchmark voltammetric uric acid (UA) sensing. Showcasing a wide linear range of UA detection with high sensitivity and low detection limit, this SAS strategy coalesces ambient condition synthesis and nanoparticle size control, paving a green way to advanced sensors.