Polysaccharide‐Based Stimulus‐Responsive Nanomedicines for Combination Cancer Immunotherapy

Author:

Li Qiuxia1,Liu Xing1ORCID,Yan Chunmei1,Zhao Bolin1,Zhao Yuxin1,Yang Lu2,Shi Mingyi3,Yu Hua4,Li Xiaofang1,Luo Kaipei1ORCID

Affiliation:

1. State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 611130 China

2. Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

3. School of Intelligent Medicine Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

4. Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese Medicine University of Macau Taipa Macao SAR 999078 China

Abstract

AbstractCancer immunotherapy is a promising antitumor approach, whereas nontherapeutic side effects, tumor microenvironment (TME) intricacy, and low tumor immunogenicity limit its therapeutic efficacy. In recent years, combination immunotherapy with other therapies has been proven to considerably increase antitumor efficacy. However, achieving codelivery of the drugs to the tumor site remains a major challenge. Stimulus‐responsive nanodelivery systems show controlled drug delivery and precise drug release. Polysaccharides, a family of potential biomaterials, are widely used in the development of stimulus‐responsive nanomedicines due to their unique physicochemical properties, biocompatibility, and modifiability. Here, the antitumor activity of polysaccharides and several combined immunotherapy strategies (e.g., immunotherapy combined with chemotherapy, photodynamic therapy, or photothermal therapy) are summarized. More importantly, the recent progress of polysaccharide‐based stimulus‐responsive nanomedicines for combination cancer immunotherapy is discussed, with the focus on construction of nanomedicine, targeted delivery, drug release, and enhanced antitumor effects. Finally, the limitations and application prospects of this new field are discussed.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Natural Science Foundation of Sichuan Province

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

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