Affiliation:
1. School of Life Sciences and Health Engineering Jiangnan University Wuxi 214122 China
2. School of Chemical and Material Engineering Jiangnan University Wuxi 214122 China
3. Department of Paediatrics University of Oxford Oxford OX1 3QX UK
4. Tumor Precise Intervention and Translational Medicine Laboratory The Affiliated Taian City Central Hospital of Qingdao University Taian 271000 China
5. MDUK Oxford Neuromuscular Centre University of Oxford Oxford OX1 3QX UK
Abstract
AbstractMetal‐organic frameworks (MOFs) have emerged as promising novel therapeutics for treating malignancies due to their tunable porosity, biocompatibility, and modularity to functionalize with various chemotherapeutics drugs. However, the design and synthesis of dual‐stimuli responsive MOFs for controlled drug release in tumor microenvironments are vitally essential but still challenging. Meanwhile, the catalytic effect of metal ions selection and ratio optimization in MOFs for enhanced chemodynamic therapy (CDT) is relatively unexplored. Herein, a series of MnFe‐based MOFs with pH/glutathione (GSH)‐sensitivity are synthesized and then combined with gold nanoparticles (Au NPs) and cisplatin prodrugs (DSCP) as a cascade nanoreactor (SMnFeCGH) for chemo‐chemodynamic‐starvation synergistic therapy. H+ and GSH can specifically activate the optimal SMnFeCGH nanoparticles in cancer cells to release Mn2+/4+/Fe2+/3+, Au NPs, and DSCP rapidly. The optimal ratio of Mn/Fe shows excellent H2O2 decomposition efficiency for accelerating CDT. Au NPs can cut off the energy supply to cancer cells for starvation therapy and strengthen CDT by providing large amounts of H2O2. Then H2O2 is catalyzed by Mn2+/Fe2+ to generate highly toxic •OH with the depletion of GSH. Meanwhile, the reduced DSCP accelerates cancer cell regression for chemotherapy. The ultrasensitivity cascade nanoreactor can enhance the anticancer therapeutic effect by combining chemotherapy, CDT, and starvation therapy.
Funder
National Basic Research Program of China
Natural Science Foundation of Jiangsu Province
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
5 articles.
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